Dr. Fadi J Charchar

Qualifications:

• B.Sc. (La Trobe, Melb), PhD (Melb)
• FAHA

Teaching Areas:

• Human Genetics
• Molecular Biology

Research Interests:

My research interests centre on molecular genetics of complex disease.

This includes:

• Genetics of cardiovascular diseases.
• Sexual dimorphism of cardiovascular risk.
• Inflammatory markers and cardiovascular system.
• The contribution of copy number variation to disease
• Evolution of disease

Membership (Professional Associations)

• Fellow of the American Heart Association (AHA) - Council for High Blood Pressure Research and Council on Kidney in Cardiovascular Disease
• International and European Society of Hypertension (ESH-ISH)
• British Society for Endocrinology
• Genetic Society of Australia

Selected Publications

Clemitson JR, Dixon RJ, Haines S, Bingham AJ, Patel BR, Hall L, Lo M, Sassard J, Charchar FJ, Samani NJ. Genetic dissection of a blood pressure quantitative trait locus on rat chromosome 1 and gene expression analysis identifies SPON1 as a novel candidate hypertension gene. Circ Res. 2007; 100: 992-999.

Charchar FJ, Shankar RR, Eckert GJ, Saha C, Tu W, Dominiczak AF, Pratt JH. Studies of an association in boys of blood pressure and the Y chromosome. Am J Hypertens. 2007; 20: 27-31.

Tomaszewski M, Charchar FJ, Lynch MD, Padmanabhan S, Wang WY, Miller WH, Grzeszczak W, Maric C, Zukowska-Szczechowska E, Dominiczak AF. Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis. Circulation. 2007; 116: 1915-1924.

Tomaszewski M, Charchar FJ, Maric C, McClure J, Crawford L, Grzeszczak W, Sattar N, Zukowska-Szczechowska E, Dominiczak AF. Glomerular hyperfiltration: a new marker of metabolic risk. Kidney Int. 2007; 71: 816-821.

Charchar FJ, Tomaszewski M, Lacka B, Zakrzewski J, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Association of the human Y chromosome with cholesterol levels in the general population. Arterioscler Thromb Vasc Biol. 2004; 24: 308-312.

Charchar FJ, Svartman M, El-Mogharbel N, Ventura M, Kirby P, Matarazzo MR, Ciccodicola A, Rocchi M, D'Esposito M, Graves JA. Complex events in the evolution of the human pseudoautosomal region 2 (PAR2). Genome Res. 2003; 13: 281-286.

Chapman MA, Charchar FJ, Kinston S, Bird CP, Grafham D, Rogers J, Grutzner F, Graves JA, Green AR, Gottgens B. Comparative and functional analyses of LYL1 loci establish marsupial sequences as a model for phylogenetic footprinting. Genomics. 2003; 81: 249-259.

Charchar FJ, Tomaszewski M, Padmanabhan S, Lacka B, Upton MN, Inglis GC, Anderson NH, McConnachie A, Zukowska-Szczechowska E, Grzeszczak W, Connell JM, Watt GC, Dominiczak AF. The Y chromosome effect on blood pressure in two European populations. Hypertension. 2002; 39: 353-356.

Charchar FJ, Kapuscinski M, Harrap SB. Persistent reduction in renal nerve growth factor mRNA after perindopril treatment of young spontaneously hypertensive rats. Hypertension. 1998; 31: 678-683.

Reviews, book chapters and editorials

M. Tomaszewski, NJR. Brain, F.J. Charchar, AF. Dominiczak: Genetics of human essential hypertension - from single mutations to quantitative trait loci. In: R.N. Re et al. Molecular Mechanisms in Hypertension. Abingdon: Taylor and Francis Medical Books, 2006:241-248.

F.J. Charchar, M. Tomaszewski, A.F. Dominiczak: Hypertension genetics - under pressure. In: Encyclopaedia of genetics, genomics, proteomics and bioinformatics. John Wiley and Sons, Ltd. 2005:491-496.

M. Tomaszewski, L. Zimmerli, F.J. Charchar, A.F. Dominiczak. Genetic information in the diagnosis and treatment of hypertension. Current Hypertension Reports 2006;8:309-316.

Dominiczak AF. Graham D. McBride MW. Brain NJ. Lee WK. Charchar F.J. Tomaszewski M. Delles C. Hamilton CA. Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension 2005;45:636-42.

Tomaszewski M. Charchar F.J. Padmanabhan S. Zukowska-Szczechowska E. Grzeszczak W. Dominiczak AF. Cardiovascular diseases and G-protein beta3 subunit gene (GNB3) in the era of genomewide scans. Journal of Human Hypertension 2003;17:379-80.

Charchar F.J. Tomaszewski M. Strahorn P. Champagne B. Dominiczak AF. Y is there a risk to being male?. Trends in Endocrinology & Metabolism 2003;14:163-8, 2003